Table 4.
Association between CYP2E1 (RsaI) polymorphism and clinicopathological characteristics
| Variables | Cases (n = 86) | ||||
|---|---|---|---|---|---|
| n = 86 | c1/c1 46 (53.5%) |
c1/c2 15 (17.4%) |
c2/c2 25 (29.1%) |
χ2; p value | |
| Age group | |||||
| ≤ 50 | 30 (34.9%) | 21 | 5 | 4 | 6.29; 0.04 |
| > 50 | 56 (65.1%) | 25 | 10 | 21 | |
| Gender | |||||
| Female | 37 (43.0%) | 20 | 6 | 11 | 0.07; 0.96 |
| Male | 49 (67.0%) | 26 | 9 | 14 | |
| Dwelling | |||||
| Rural | 59 (68.6%) | 27 | 11 | 21 | 5.0; 0.08 |
| Urban | 27 (31.4%) | 19 | 4 | 4 | |
| Smoking status | |||||
| Ever | 55 (64.0%) | 29 | 8 | 18 | 1.45; 0.48 |
| Never | 31 (36.0%) | 17 | 7 | 7 | |
| Tumour location | |||||
| Colon | 36 (41.9%) | 19 | 5 | 12 | 0.84; 0.65 |
| Rectum | 50 (58.1%) | 27 | 10 | 13 | |
| Nodal status | |||||
| Involved | 48 (55.8%) | 24 | 4 | 20 | 11.34; 0.003 |
| Not Involved | 38 (44.2%) | 22 | 11 | 5 | |
| Tumour grade | |||||
| A + B | 38 (44.2%) | 22 | 11 | 5 | 11.34; 0.003 |
| C + D | 48 (55.8%) | 24 | 4 | 20 | |
| Pesticide exposure | |||||
| Ever | 53 (61.6%) | 26 | 8 | 19 | 3.13; 0.20 |
| Never | 33 (38.4%) | 20 | 7 | 6 | |
| Bleeding PR/constipation | |||||
| Yes | 60 (69.8%) | 32 | 10 | 18 | 0.13; 0.93 |
| No | 26 (30.2%) | 14 | 5 | 7 | |
| Tumour typea | |||||
| Mucinous | 33 (38.5%) | 20 | 6 | 7 | 1.84; 0.39 |
| Non-mucinous | 52 (60.5%) | 25 | 9 | 18 |
aOne was squamous cell carcinoma. Significant p values are shown in bold.