Table 5.
Association between CYP2E1 (96 bp) polymorphism and clinicopathological characteristics
| Variables | Cases (n = 86) | ||||
|---|---|---|---|---|---|
| n = 86 | i/i 55 (63.9%) | i/I 19 (22.1%) | I/I 12 (13.9%) | χ2; p value | |
| Age group | |||||
| ≤ 50 | 30 (34.9%) | 19 | 7 | 4 | 0.05; 0.97 |
| > 50 | 56 (65.1%) | 36 | 12 | 8 | |
| Gender | |||||
| Female | 37 (43.0%) | 26 | 8 | 3 | 2.0; 0.36 |
| Male | 49 (67.0%) | 29 | 11 | 9 | |
| Dwelling | |||||
| Rural | 59 (68.6%) | 38 | 13 | 8 | 0.03; 0.98 |
| Urban | 27 (31.4%) | 17 | 6 | 4 | |
| Smoking status | |||||
| Ever | 55 (64.0%) | 35 | 10 | 10 | 3.01; 0.22 |
| Never | 31 (36.0%) | 20 | 9 | 2 | |
| Tumour location | |||||
| Colon | 36 (41.9%) | 22 | 5 | 9 | 7.38; 0.02 |
| Rectum | 50 (58.1%) | 33 | 14 | 3 | |
| Nodal status | |||||
| Involved | 48 (55.8%) | 28 | 12 | 8 | 1.53; 0.46 |
| Not Involved | 38 (44.2%) | 27 | 7 | 4 | |
| Tumour grade | |||||
| A + B | 38 (44.2%) | 27 | 7 | 4 | 1.53; 0.46 |
| C + D | 48 (55.8%) | 28 | 12 | 8 | |
| Pesticide exposure | |||||
| Ever | 53 (61.6%) | 38 | 9 | 6 | 3.62; 0.16 |
| Never | 33 (38.4%) | 17 | 10 | 6 | |
| Bleeding PR/constipation | |||||
| Yes | 60 (69.8%) | 42 | 11 | 7 | 3.15; 0.20 |
| No | 26 (30.2%) | 13 | 8 | 5 | |
| Tumour type* | |||||
| Mucinous | 33 (38.5%) | 22 | 7 | 4 | 0.27; 0.87 |
| Non-mucinous | 52 (60.5%) | 32 | 12 | 8 |
*One was squamous cell carcinoma. Significant p values are shown in bold.