Table 3.
Family-based association test analysis of individual CYP27A1, CYP27B1, VDR and CYP24A1 SNPs in discovery cohort
| Marker | Allele | Frequency | Informative families | Z score | p-Value |
|---|---|---|---|---|---|
| CYP27A1 | |||||
| rs7594289 | G | 0.428 | 51 | -0.808 | 0.4189 |
| rs7566656 | A | 0.485 | 60 | 1.179 | 0.2383 |
| CYP27B1 | |||||
| rs8176345 | A | 0.030 | < 2 | 0.000 | 1.0000 |
| rs4646536 | C | 0.324 | < 2 | 0.000 | 1.0000 |
| VDR | |||||
| rs4516035 | G | 0.443 | 47 | 1.116 | 0.2643 |
| rs7299460 | A | 0.262 | 36 | 1.333 | 0.1824 |
| rs10783219 | A | 0.361 | 42 | -0.630 | 0.5287 |
| rs7136534 | A | 0.238 | 35 | 1.622 | 0.1048 |
| rs11574026 | T | 0.120 | 23 | 0.626 | 0.5316 |
| rs11574027 | T | 0.017 | 2 | 1.414 | 0.1573 |
| rs4237855 | T | 0.490 | 47 | -0.329 | 0.7419 |
| rs4328262 | A | 0.568 | 49 | 0.956 | 0.3390 |
| rs11168287 | C | 0.485 | 56 | -0.570 | 0.5688 |
| rs4760648 | A | 0.447 | 52 | -0.640 | 0.5221 |
| rs2853564 | C | 0.395 | 46 | 0.000 | 1.0000 |
| rs2238136 | A | 0.283 | 43 | -1.000 | 0.3173 |
| rs2254210 | T | 0.369 | 54 | 0.843 | 0.3994 |
| rs10735810 | T | 0.374 | 48 | 0.739 | 0.4602 |
| rs10875693 | A | 0.679 | 46 | 0.000 | 1.0000 |
| rs2239186 | C | 0.248 | 44 | -0.137 | 0.8907 |
| rs3782905 | G | 0.282 | 34 | -0.152 | 0.8788 |
| rs3819545 | C | 0.427 | 54 | 0.226 | 0.8208 |
| rs2189480 | C | 0.593 | 45 | -1.807 | 0.0707 |
| rs12721370 | T | 0.112 | 15 | 1.414 | 0.1573 |
| rs12717991 | G | 0.564 | 51 | 0.000 | 1.0000 |
| rs2239179 | G | 0.349 | 47 | -0.911 | 0.3621 |
| rs2283342 | C | 0.205 | 38 | -0.302 | 0.7630 |
| rs2107301 | T | 0.340 | 46 | 0.405 | 0.6858 |
| rs2239182 | G | 0.420 | 46 | 0.788 | 0.4308 |
| rs11574077 | G | 0.028 | 10 | -0.632 | 0.5271 |
| rs11168267 | T | 0.116 | 17 | 0.728 | 0.4669 |
| rs7975128 | T | 0.333 | 45 | 0.132 | 0.8946 |
| rs1544410 | A | 0.337 | 46 | -0.640 | 0.5221 |
| rs7975232 | T | 0.494 | 52 | 0.239 | 0.8111 |
| rs731236 | C | 0.320 | 45 | -0.775 | 0.4386 |
| rs3847987 | T | 0.150 | 28 | 1.029 | 0.3035 |
| CYP24A1 | |||||
| rs2248359 | A | 0.425 | 49 | -0.611 | 0.5413 |
| rs6022999 | C | 0.250 | 42 | -1.089 | 0.2763 |
| rs2585428 | A | 0.441 | 56 | -0.342 | 0.7324 |
| rs2245153 | G | 0.201 | 48 | 1.089 | 0.2763 |
| rs4809960 | G | 0.229 | 51 | 1.192 | 0.2332 |
| rs4809959 | C | 0.500 | 46 | 0.122 | 0.9028 |
| rs2181874 | T | 0.247 | 45 | -1.633 | 0.1025 |
| rs3787557 | G | 0.144 | 40 | 1.265 | 0.2059 |
| rs3787555 | T | 0.263 | 42 | 1.260 | 0.2076 |
| rs3787554 | T | 0.065 | 20 | 0.209 | 0.8348 |
| rs4809958 | C | 0.128 | 25 | 1.134 | 0.2568 |
| rs2762939 | G | 0.275 | 36 | -0.816 | 0.4142 |
| rs6068816 | A | 0.079 | 22 | 0.000 | 1.0000 |
| rs6127118 | T | 0.157 | 22 | 2.132 | 0.0330 |
| rs2209314 | G | 0.256 | 43 | -1.387 | 0.1655 |
| rs1570669 | C | 0.335 | 45 | 0.630 | 0.5287 |
| rs927650 | G | 0.511 | 44 | -0.391 | 0.6961 |
| rs2762934 | T | 0.156 | 29 | -2.535 | 0.0112 |
| rs6097807 | C | 0.241 | 50 | -1.131 | 0.2579 |
| rs6068810 | A | 0.059 | 17 | 0.728 | 0.4669 |