Table 1.

Gene expression profile, characteristic mutations, and survival of glioblastoma subtypes^a

Abbreviations: DNA meth = DNA methylation profile; EGFR mut = epidermal growth factor receptor gene mutation; G-CIMP = CpG hypermethylator phenotype; GB = glioblastoma; gene exp = genetic expression profile; IDH1 mut = isocitrate dehydrogenase 1 gene mutation; NF-1 mut = neurofibromatosis type 1 gene mutation; OS = overall survival.

^a Glioblastoma subtypes separated into 3 groups based on DNA methylation and gene expression profile. Characteristic gene mutations enriched within each group are annotated. Group 1 has markedly improved survival outcomes compared to groups 2 and 3.

^b A small percentage of G-CIMP (+) GBs have non-proneural genetic signatures or are IDH1 wild-type.

^c References ⁴² and ⁵⁷.

^d References ⁵¹ and ⁵².

^e Non-mesenchymal, G-CIMP (−) GBs including proneural, neural, and classical genetic subtypes have similar outcomes to mesenchymal GBs.