Table 2.

Molecular classification and survival of low-grade and anaplastic gliomas^a

Abbreviations: Codel = chromosomal codeletion; IDH1 or 2 mut = isocitrate dehydrogenase 1 or 2 gene mutation; OS = overall survival.

^a Classification of diffuse gliomas based on WHO grade and prognostic biomarkers. Low grade and anaplastic gliomas are divided into groups 1, 2, 3 based on biomarker characteristics. Median OS was estimated based on the current literature. Due to prolonged survival times, median OS has not been reached in many studies of 1p/19q codel or IDH1 or 2 mut grade II and III diffuse gliomas. 1p/19q codel, low grade, and anaplastic gliomas have the best outcomes, and are nearly always mutated on IDH1 or 2. Low grade and anaplastic gliomas intact on 1p/19q and wild type on IDH1 and 2 have markedly inferior survival rates.

^b References 45–48.

^c References 18, 47, and 48.

^d References 44, 45, and 47.

^e References 5, 21, and 47.