Table 2.

Cox proportional hazard models of association with incident AD by timing, duration, and type of HT

Abbreviations: AD = Alzheimer disease; CI = confidence interval; HR = hazard ratio; HT = hormone therapy; P-Y = person-years of observation.

^aThe numbers in this column do not add up to 1,768 in all cases because of missing data on timing, duration, or type of HT.

^bAdjusted for baseline age, APOE status (ε4 vs no ε4), and years of education.

^cAdjusted for baseline age, APOE status, years of education, and decile propensity score (see Methods).

^dStatistically significant at p < 0.05.

^eModel 6 categorizes HT use into mutually exclusive groups of those who initiated HT within 5 years of menopause, those who did not initiate HT within 5 years of menopause but did so >3 years before baseline, and those who did not initiate HT within 5 years of menopause but did so within 3 years of baseline. The latter group captures risk associated with recent initiation of HT.