Table II.
Alterations of hMSH2, hMLH1, hMSH6 and hPMS2 mRNA levels between paired bladder tumor and adjacent normal tissues relative to their clinicopathological parameters.
| Relative copies of hMSH2 mRNA
|
Relative copies of hMLH1 mRNA
|
Relative copies of hMSH6 mRNA
|
Relative copies of hPMS2 mRNA
|
Tumor/ANT MMR mRNA gene expression
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | n | Tumor | ANT | Tumor | ANT | Tumor | ANT | Tumor | ANT | hMSH2 | hMLH1 | hMSH6 | hPMS2 |
| All patients | 24 | 3.77a,b | 3.06 | 8.69e | 7 | 16 | 12 | 12.9j | 18.34 | 2.4n | 2.4 | 2.19 | 1.52 |
| Gender | |||||||||||||
| Male | 20 | 3.93c | 2.37 | 8.23f | 6 | 19 | 14 | 14.9k | 16.41 | 2.75o | 2.79 | 2.43 | 1.68 |
| Female | 4 | 2.96 | 6.54 | 11 | 12 | 1.6 | 1.6 | 3.03 | 28 | 0.85p,v | 0.9w,y | 1.3z | 0.77 |
| Tumor type | |||||||||||||
| PUNLMP | 1 | 0.46 | 2.9 | 0.22 | 0.2 | 0.74 | 1.1 | 1.59 | 3.87 | 0.16 | 0.67 | 0.4 | 0.9 |
| UCC | 23 | 3.9 | 3.07 | 9.06 | 7.3 | 16.7 | 12.5 | 13.42 | 18.97 | 2.5q | 2.66 | 2.33 | 1.55 |
| Tumor stage | |||||||||||||
| Ta | 7 (6LG+1HG) | 3.3d | 1.98 | 7.65 | 6.26 | 26.3 | 20.8 | 11.05 | 10.1 | 2.62r | 1.73x | 1.5 | 2.8 |
| T1 | 15 (7LG+8HG) | 4.35 | 3.73 | 9.86g | 8.09 | 13.13 | 9.34 | 13.04l | 24.25 | 2.51s | 1.89 | 1.24 | 2.07 |
| T2 | 1 (HG) | 1.63 | 0.7 | 7 | 2.1 | 2.19 | 0.74 | 35.7 | 1.8 | 2.3 | 2.9 | 19.9 | 3.3 |
| Tumor grade | |||||||||||||
| LG | 13 (6Ta+7T1) | 3.71 | 4.27 | 10.6h | 8.96 | 15.1 | 12 | 8.8 | 17.35 | 2.06t | 1.64 | 1.11 | 2.17 |
| HG | 10 (1Ta+9T1) | 4.17 | 1.5 | 7.07i | 5.08 | 18.79 | 13.1 | 19.42m | 21.08 | 3.15u | 2.21 | 3.45 | 2.59 |
Mean age of the patients was 72 years. ANT, adjacent normal tissue; MMR, mismatch repair; PUNLMP, papillary urothelial neoplasm of low malignant potential; UCC, urothelial cell carcinoma; LG, low grade; HG, high grade.
r=0.795, by Pearson test; correlation between hMSH2/hPBGD and hMSH6/hPBGD mRNA ratios.
P=0.019165,
P=0.020265,
P=0.048544,
P=0.000,
P=0.000366,
P=0.012455,
P=0.012,
P=0.032,
P=0.005896,
P=0.005159,
P=0.038387,
P=0.028778; by Student’s t-test.
r=0.415684,
r=0.37,
r=0.873155,
r=0.44,
r=0.778713,
r=0.613262,
r=0.700724,
r=0.598678; by Pearson test, correlation between hMSH2 and hMLH1 mRNA ratios of tumor/ANT.
r=0.735679 by Pearson test, correlation between hMSH2 and hMSH6 mRNA ratios of tumor/ANT.
r=0.728012,
r=0.567703 by Pearson test, correlation between hMLH1 and hMSH6 mRNA ratios of tumor/ANT.
r=0.560746 Pearson test, correlation between hMLH1 and hPMS2 mRNA ratios of tumor/ANT.
r=0.801165 Pearson test, correlation between hMSH6 and hPMS2 mRNA ratios of tumor/ANT.