Table III.
Distribution of individual hMSH2, hMLH1, hMSH6 and hPMS2 mRNA phenotypes in UCCs and their ANTs.
| MMR mRNA phenotype | UCC (n) | UCC observed phenotypic frequency | Grade (n)
|
Stage (n)
|
ANT (n) | ANT observed phenotypic frequency | Samples (n)
|
|||
|---|---|---|---|---|---|---|---|---|---|---|
| LG | HG | pTa | pT1–2 | PUNLMP | ANT | |||||
| hMSH2 | ||||||||||
| r2 | 5 | 0.2174 | 1 | 4 | 1 (HG) | 4 (1LG+3HG) | 11 | 0.4783 | 1 | |
| R2 | 18 | 0.7826 | 12 | 6 | 6 (LG) | 12 (6LG+6HG) | 12 | 0.5217 | 1 | |
| hMLH1 | ||||||||||
| r1 | 0 | 0.000 | 0 | 0 | 0 | 0 | 0 | 0.000 | 1 | 1 |
| R1 | 23 | 1.000 | 13 | 10 | 7 (1LG+6HG) | 16 (7LG+9HG) | 23 | 1.000 | ||
| hMSH6 | ||||||||||
| r6 | 6 | 0.2609 | 2 | 4 | 1 (HG) | 5 (2LG+3HG) | 10 | 0.4348 | 1 | |
| R6 | 17 | 0.7391 | 11 | 6 | 6 (LG) | 11 (5LG+6HG) | 13 | 0.5652 | 1 | |
| hPMS2 | ||||||||||
| p2 | 3 | 0.1304 | 1 | 2 | 1 (HG) | 2 (1LG+1HG) | 3 | 0.1304 | ||
| P2 | 20 | 0.8696 | 12 | 8 | 6 (LG) | 14 (6LG+8HG) | 20 | 0.8696 | 1 | 1 |
ANT, adjacent normal tissue; MMR, mismatch repair; UCC, urothelial cell carcinoma; LG, low grade; HG, high grade; PUNLMP, papillary urothelial neoplasm of low malignant potential; pTa, limited to mucosa; pT1, lamina propria invasion; pT2, invasion of the muscularis; r/p, reduced, mRNA ratio <1; R/P, normal/elevated, mRNA ratio ≥1; r/R2, hMSH2; r/R1, hMLH1; r/R6, hMSH6; p/P2, hPMS2.