Abstract
The antiviral compound trisodium phosphonoformate (PFA), which inhibits herpesvirus multiplication by 50% at a concentration of 10 μM, did not show any effects on macromolecular synthesis and cell proliferation in HeLa and human lung cells at this concentration. At the high concentration of 2 mM, PFA reduced DNA synthesis to 50% after 1 h of treatment, whereas no effects could be seen on RNA and protein synthesis. Treatment for 24 h with 1 mM PFA inhibited both DNA synthesis and cell proliferation to 50%. The inhibition of DNA synthesis and cell proliferation at 10 mM PFA was rapidly reversed by removing the drug from the cells.
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Selected References
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- Alenius S., Dinter Z., Oberg B. Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs. Antimicrob Agents Chemother. 1978 Sep;14(3):408–413. doi: 10.1128/aac.14.3.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Helgstrand E., Eriksson B., Johansson N. G., Lannerö B., Larsson A., Misiorny A., Norén J. O., Sjöberg B., Stenberg K., Stening G. Trisodium phosphonoformate, a new antiviral compound. Science. 1978 Sep 1;201(4358):819–821. doi: 10.1126/science.210500. [DOI] [PubMed] [Google Scholar]
- Larsson A., Stenberg K., Oberg B. Reversible inhibition of cellular metabolism by ribavirin. Antimicrob Agents Chemother. 1978 Feb;13(2):154–158. doi: 10.1128/aac.13.2.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reno J. M., Lee L. F., Boezi J. A. Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate. Antimicrob Agents Chemother. 1978 Feb;13(2):188–192. doi: 10.1128/aac.13.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sabourin C. L., Reno J. M., Boezi J. A. Inhibition of eucaryotic DNA polymerases by phosphonoacetate and phosphonoformate. Arch Biochem Biophys. 1978 Apr 15;187(1):96–101. doi: 10.1016/0003-9861(78)90010-3. [DOI] [PubMed] [Google Scholar]