Table III.
KIT and PDGFRα mutational rates in various populations.
| Country | Gene | Number of studies/total sample number | Mutated exons (%)
|
Reference | |||||
|---|---|---|---|---|---|---|---|---|---|
|
KIT
|
PDGFRα
|
||||||||
| 11 | 9 | 13 | 17 | 18 | 12 | ||||
| Taiwan | KIT | 2/188 | 66.1 | 14.2 | 0.0 | 0.0 | - | - | 20, 28 |
| PDGFRα | 1/134 | - | - | - | - | 0.0 | 0.8 | ||
| Japan | KIT | 2/118 | 58.7 | 7.0 | 0.0 | NP | - | - | 30–32 |
| PDGFRα | 1/70 | - | - | - | - | 4.3 | 2.9 | ||
| China | KIT | 1/165 | 63.0 | 6.6 | 1.3 | 0.6 | - | - | 29 |
| PDGFRα | 1/165 | - | - | - | - | 3.0 | 0.0 | ||
| Brazil | KIT | 1/55 | 69.0 | 3.6 | 0.0 | 0.0 | - | - | 33 |
| PDGFRα | 1/55 | - | - | - | - | 1.8 | 5.5 | ||
| Spain | KIT | 1/166 | 47.5 | 2.4 | 0.6 | 1.6 | - | - | 27 |
| PDGFRα | 1/166 | - | - | - | - | 4.0 | 4.0 | ||
| USA | KIT | 4/818 | 56.5 | 8.9 | 0.4 | 0.6 | - | - | 5,21–23 |
| PDGFRα | 3/693 | - | - | - | - | 8.1 | 0.7 | ||
| Europe | KIT | 3/591 | 62.6 | 9.9 | 1.4 | 0.45 | - | - | 24–26 |
| PDGFRα | 3/579 | - | - | - | - | 3.9 | 0.8 | ||
| South Africa | KIT | 1/46 | 69.6 | 2.8 | 0.0 | 0.0 | - | - | Present study |
| PDGFRα | 1/46 | - | - | - | - | 6.5 | 0.0 | ||
NP, not performed.