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Sensitivity of the four cancer cell lines to 5FU expressed as IC60 values, p53 and MMR genes status.
| Cell line | p53 status | MMR status | IC60 (μg/ml) | Ref. |
|---|---|---|---|---|
| HCT116 | WT | Deficient | 2.2±0.30 | (25) |
| HepG2 | WT | Proficient | 7±0.20 | (26) |
| MCF-7 | WT | Proficient | 24.5±0.60 | (27) |
| HeLa | WT | Proficient | 50±1.30 | (28) |
p53, tumour suppressor 53 gene; MMR, DNA mismatch repair gene; WT, wild-type; IC60, 5FU concentration that results in 40% cell death compared with control cell growth.
