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. 2012 Oct 31;5(1):76–82. doi: 10.3892/ol.2012.1009

Figure 4.

Figure 4

Changes in the expression of proliferative cellular nuclear antigen (PCNA)-positive acinar cells in a 60-day-old rat treated with 35 mg/kg N-methyl-N-nitrosourea (MNU) at birth (day 0). (A) The number of PCNA-positive acinar cells in both the normal and hyperplastic areas increased in MNU-treated rats as compared to vehicle controls. In the MNU-treated rats fed arachidonic acid (AA)-rich food, the number was significantly larger than in the basal food group. Mean ± standard error, where each bar represents 5–10 rats. *P<0.05. (b) Images of immunohistochemistry for PCNA. Proliferative activity of acinar cells was higher in MNU-treated rats fed an AA-rich food than in the basal food group. H, acinar cell hyperplasia (ACH); N, normal area. Bar=100 μm.