Figure 4. Comparison of COPS to two other computational approaches.

The plots depict the Matthews Correlation Coefficient (MCC) values as determined using COPS and the published tools CPModule and ModuleDigger, for the co-occurrence patterns Bap/Twi, Tin/Twi, Ase/Pros and Snail/Pros in sequence-sets of increasing size (ranging from 50 to 300 sequences). The MCC values used for evaluating the performance of the different computational tools were calculated as described in the Materials and Methods. The red line illustrates the performance of COPS, the blue line CPModule and the green line ModuleDigger.