Table 1. Infected hepatocytes present a PbCSP-specific epitope to primed CD8+ T-cells and protect mice against SPZ challenge.

	Treatment
TAP−/− mouse group	BALB/c- SPZ infected hepatocytes	T cell clones	Mice protected/total injected	% of protection	p-value
A	yes	C7	8/8	100	A versus B  = 0.006
B	yes	S14	0/3	0	B versus C = 1
C	yes	None	1/4	25	A versus C  = 0.018

Each recipient TAP−/− mouse (H-2K^b) received 7×10⁵ PbSPZ-infected BALB/c (H-2k^d) hepatocytes by IS transfer as described in Materials and Methods. Before IS injection, infected hepatocytes were isolated from BALB/c mice that were injected (iv) with 10⁶ ANKA wt PbSPZ 2 h earlier. C7 and S14 (20 million cells per mouse, iv) were injected into the corresponding group 4 h after IS transfer. Mice were protected if they remained parasite negative 2 weeks after infected hepatocyte transfer.