Table 5. MS concordance rates in monozygotic twins of DRB1^*1501 carrier (HLA+) and DRB1^*1501 non-carrier (HLA–) probands^*.

	Monozygotic Twins of MS Probands
	HLA+	HLA–	Totals
Concordant for MS (C)	9	11	20
Discordant for MS (D)	31	42	73
Totals	40	53	93
Pair-wise Concordance †	(9/40)  =  0.225	(11/53)  =  0.207	0.215
Proband-wise Concordance ††	0.309	0.287	0.297
Proband-wise Concordance (Adjusted) †††	t  =  0.166	s  =  0.154	b  =  0.160
Proband-wise Concordance (Adjusted) ††††	t  =  0.139	s  =  0.129	b  =  0.134
P(HLA+|MS, IG MS) (Adjusted) #	0.57

^* (HLA+)  =  carrier of ≥1 copy of the DRB1*1501 allele; Data from: Reference [21].

^†Pair-wise rates (Z₁) calculated as: ; see Reference [30]

^††Proband-wise concordance rates (Z₂) calculated as: ; adjusted [30] for the overall probability of doubly ascertaining concordant twin-pairs in the study of Willer, et al. [21]

^†††For adjustment: See: Prop. (1.4a) (1.4b) of Appendix S1 (Section C)

^††††Further adjusted to the requirement that: b  =  0.134

^#Adjusted to the condition where: