Table 6. MS concordance rates in monozygotic twins of female (F) and male (M) probands^*.

	Monozygotic Twins of MS Probands
	F	M	Totals
Concordant for MS (C)	22	2	24
Discordant for MS (D)	66	43	109
Totals	88	45	133
Pair-wise Concordance †	(22/88)  =  0.25	(2/45)  =  0.044	0.18
Proband-wise Concordance ††	0.34	0.067	0.25
Proband-wise Concordance (Adjusted) †††	t  =  0.183	s  =  0.036	b  =  0.134
P(F|MS, IG MS) (Adjusted) #	0.92

^* (F)  =  Women ; (M)  =  Men ; Data from: Reference [21]

^†Pair-wise rates (Z₁) calculated as: ; see Ref. [30]

^††Proband-wise concordance rates (Z₂) calculated as: ; adjusted [30] for the overall probability of doubly ascertaining concordant twin-pairs in the study of Willer, et al. [21]

^†††For adjustment: See: Prop. (1.4a) & (1.4b) of Appendix S1 (Section C)

^#Adjusted to the condition where: