Table 5. Logistic regression modeling of high throughput protein assay.

Protein	P-value
Lymphangiogenesis
FGFb	0.03
Inflammation
IL4	0.04
IL10	0.05
TNFb	0.3
Fibrosis
TGFb	0.004
Adipocytokine signaling
Leptin	1.8×10−5

Eighteen proteins were assayed by the Luminex bead assay, comparing the sera of 27 lymphedema subjects with 12 healthy controls. The p-values reflect the significance of differences between lymphedema subjects and normals. Of note is the fact that leptin is highly differentially detected in lymphedema vs. normal, despite the absence of differential expression by transcriptomic analysis. FGFb, basic fibroblast growth factor; IL4, interleukin 4; IL10, interleukin 10; TNFb, tumor necrosis factor beta; TGFb, transforming growth factor beta.