Figure 2. SLC22A1 haplotypes association with imatinib pharmacokinetics in Asian patients with CML (n = 38).

The patients were divided in two groups according to copy numbers of SLC22A1 haplotypes AGT and CGC, S_low (0 or 1 copy) and S_high (2 copies). SLC22A1 haplotypes were significantly associated with imatinib (A) clearance, CL and (B) trough concentration, C_0h. Patients harboring S_high haplotypes had 33.4% lower clearance and 50% higher trough concentration than patients with S_low haplotypes_.