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. 2012 Dec 18;7(12):e51771. doi: 10.1371/journal.pone.0051771

Table 3. Influence of SLC22A1 haplotypes on imatinib clearance, CL and trough concentration, C0h using haplotype specific generalized linear model.

Haplotypes Haplotype frequency (%) Mean ± SE Fold change p-value
IVS6 -878C>A 1222A>G IVS7+850C>T CMLPatients Healthy Chinese CL(*10−2 L/hr/mg ) C0h(*10−6 1/ml) CL C0h CL C0h
C A C 22.3 25.8 4.03±0.53 3.13±1.06 1.00a 1.00a 0 0.005
A G C 1.30 0.90 6.71±1.28 0.60±2.56 1.66 0.192 0.044 0.328
A G T 40.7 38.7 3.16±0.35 4.32±0.70 0.784 1.38 0.017 0.097
C G C 35.5 30.2 3.15±0.35 4.07±0.71 0.781 1.30 0.017 0.192
a

Reference: Imatinib pharmacokinetics parameters values corresponding to haplotype CAC were used as reference to compare with other three haplotypes.