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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Clin Cancer Res. 2012 Oct 23;18(24):6784–6791. doi: 10.1158/1078-0432.CCR-12-1785

Figure 2.

Figure 2

PTEN IHC changes between pre-trastuzumab and post-trastuzumab samples. Depicted are photomicrographs of PTEN change from normal to loss of expression: a) PTEN expression by IHC in the primary breast invasive carcinoma with nuclear and cytoplasmic staining equal to the adjacent normal stroma (100X); b) HE staining of the primary lesion (100X); c) PTEN complete loss of expression in the secondary invasive carcinoma with absence of any staining in the lesion as compared to the adjacent normal stroma (100X); d) HE staining of the secondary lesion (100X).