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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2012 Nov 15;21(1):114–126. doi: 10.1016/j.bmc.2012.10.056

Table 4.

5-F-salicylic acid: aniline modifications

graphic file with name nihms427696t13.jpg
Compd 2 3 4 5 MIC (µM) IC50 (µM)
89 H CF3 H Br 3.1–6.3 4.7
90 Cl H H CF3 3.1–6.3 6.1
91 H F H F 6.3 9.6
92 H H CF3 H 3.1–6.3 5.4
93 F H H CF3 6.3 5.1
94 H CF3 H H 6.3–13 6.1