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. Author manuscript; available in PMC: 2013 Dec 14.
Published in final edited form as: Mol Cell. 2012 Oct 25;48(5):705–712. doi: 10.1016/j.molcel.2012.09.016

Figure 4. Three distinct bulging patterns and dynamics within isogenic cell populations.

Figure 4

(A) Scatter and histogram plots of bulge formation time (τB) and cracking angle (Δθ) reveal three different bulging patterns in response to cell wall damage by cephalexin: fast bulging without cracking (b, red dot, τB<10−2 min), slow bulging without cracking (c, green dot, τB>10−2 min), and slow bulging with cracking (d, blue dot, τB>10−2 min). Yellow dots and bar graphs represent slow bulging cells (top and middle panels). Gray bars represent all isogenic cells examined (N=195, right panel). (B–D) Representative bulge depth measurement and snapshots of cells before (t2) and after (t3) bulge formation for each bulging pattern. Magenta lines represent measurement of cracking angles. All scale bars represent 2 μm. See also Figure S4 and online supplementary movies for cell 6, cell 75 and cell 123.