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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Prog Neurobiol. 2012 Oct 17;100:60–80. doi: 10.1016/j.pneurobio.2012.10.001

Figure 4.

Figure 4

Fluoxetine potentiates methylphenidate-induced gene regulation. (A) Film autoradiograms depict expression of Zif268 in the middle striatum for rats that received a single injection of vehicle (V), methylphenidate (MP, 5 mg/kg), fluoxetine (FLX, 5 mg/kg), or a combination of methylphenidate plus fluoxetine (Van Waes et al., 2010). (B) Association between the potentiation of Zif268 expression (at 40 minutes; Van Waes et al., 2010) and that of substance P expression (at 90 minutes after drug injection; Van Waes et al., 2012a) in the 23 striatal sectors (open diamonds, sensorimotor; full circles, non-sensorimotor; data expressed as percentage of maximal increase). Potentiation is the difference between MP+FLX and MP groups. The potentiation was most robust in sectors of the sensorimotor striatum (open diamonds). *** p < 0.001