Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Addict Biol. 2012 Sep 12;19(4):529–538. doi: 10.1111/j.1369-1600.2012.00493.x

Figure 3.

Figure 3

Rats withdrawn from cocaine self-administration exhibited reduced basal levels of glutamate in the nucleus accumbens regardless of intake conditions or length of withdrawal. (a) Basal extracellular glutamate levels (pmole/μl) sampled using microdialysis in the nucleus accumbens of drug-naïve or rats that had self-administered cocaine under low- or high-intake conditions. * indicates a significant difference from drug-naïve controls; Fisher LSD with Bonferroni correction, p<.033). (b) Extracellular glutamate levels (pmole/μl) in the nucleus accumbens from rats withdrawn from low- or high-cocaine intake for 1, 21, or 60 days. The N/group is listed in each bar.