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FoxC1 regulates the precisely controlled balance between pro-angiogenic pathways (e.g., MMP-mediated ECM degradation and release of VEGF from the ECM, which increases VEGF bioavailability) and anti-angiogenic pathways (e.g., sVEGFR-1-mediated VEGF sequestration) in the cornea [This figure is adapted from ( Seo et al., 2012)].
