Table 1.

Eligibility Criteria

Inclusion Criteria	Exclusion Criteria
New focal disabling neurologic deficit consistent with acute cerebral ischemia (NIHSS ≥ 6 with at least six points attributed to current stroke)	NIHSS ≥ 30
Age ≥ 18 ≤ 85	Acute intracranial hemorrhage
Clot retrieval procedure can be initiated within 8 hours from onset	Coma
Large vessel proximal anterior circulation occlusion on MR or CT angiography (internal carotid, M1 or M2 MCA)	Rapidly improving neurological signs prior to randomization
Signed informed consent obtained from the patient or patient’s legally authorized representative (or via waiver of consent if IRB/FDA approved for enrollment under waiver)	Pre-existing medical, neurological or psychiatric disease that would confound the neurological, functional, or imaging evaluations
Pretreatment multimodal MRI or CT performed according to MR RESCUE protocol	Pregnancy
Premorbid modified Rankin score of 0–2	Known allergy to iodine previously refractory to pretreatment medications
Allowed but not required: patients treated with IV tPA up to 4.5 hours from symptom onset with persistent target occlusion on post-treatment MR RESCUE MR or CT protocol performed at the completion of drug infusion	Current participation in another experimental treatment protocol
	Contrast-Enhanced Neck MRA or CTA suggests proximal ICA occlusion, proximal carotid stenosis > 67%, or dissection
	INR > 3.0
	PTT > 3 × Normal
	Imaging data cannot be processed by MR RESCUE computer
	Renal failure: serum creatinine > 2.0 or GFR < 30
	MRI*: contraindication to MRI
	CT*: contraindication to iodinated contrast

^*Baseline imaging modality