Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Int J Obes (Lond). 2012 Sep 11;37(6):853–860. doi: 10.1038/ijo.2012.141

Figure 6. “Potential” hypothesis of increased inflammation and pro-angiogenesis presumably caused by adipose tissue hypoxia despite smaller adipocytes and lower adiposity in young mice.

Figure 6

A) The increase in capacity for tissue remodeling resulting from hypoxia may determine the development of obesity in the future. Reduced vascular function responding to dynamic change of nutrients or gas exchange surrounding adipocytes may result in increased hypoxia and subsequent pro-angiogenesis in white adipose tissue despite smaller adipocytes. Inflammation is accompanied by angiogenesis.

B) The adequate ability of vasculature to meet the requirements may cause resistance to obesity. Reactivity of vasculature responding to the environments may be enough to compensate for the rapid increase of need for supplying nutrients or gas exchange. Therefore, adipocytes do not need the tissue remodeling for angiogenesis.