Table 1. Individual Monitoring Parameters.
| Volunteer code | Time (h) | 0 | 1 | 6 |
|---|---|---|---|---|
| S1 | Leukocytes (109/l) | 5.8 | 6.3 | 8.0 |
| Neutrophils (109/l) | 3.5 | 4.4 | 5.7 | |
| CRP (mg/l) | 3.6 | NA | 4.4 | |
| Cortisol (nM) | 617 | NA | 320 | |
| Blood pressure (mmHg, systolic/diastolic) | 136/84 | 137/77 | 136/82 | |
| Heart rate (per min) | 68 | 67 | 69 | |
| Temperature (°C) | 36.9 | 36.7 | 36.9 | |
| J1 | Leukocytes (109/l) | 7.7 | 8.7 | 11.2 |
| Neutrophils (109/l) | 5.1 | 5.6 | 7.8 | |
| CRP (mg/l) | 7.4 | 7.2 | 6.3 | |
| Cortisol (nM) | 387 | NA | 184 | |
| Blood pressure (mmHg, systolic/diastolic) | 138/86 | 129/75 | 126/70 | |
| Heart rate (per min) | 90 | 74 | 72 | |
| Temperature (°C) | 36.7 | 36.8 | 36.6 | |
| A2 | Leukocytes (109/l) | 3.8 | 4.4 | 9.5 |
| Neutrophils (109/l) | 1.9 | 2.4 | 7.8 | |
| CRP (mg/l) | 5 | 5.1 | 4 | |
| Cortisol (nM) | 372 | NA | 259 | |
| Blood pressure (mmHg, systolic/diastolic) | 129/92 | 125/69 | 113/69 | |
| Heart rate (per min) | 67 | 62 | 61 | |
| Temperature (°C) | 35.8 | 35.9 | 36.5 | |
| Q1 | Leukocytes (109/l) | 6.1 | 7.7 | 8.3 |
| Neutrophils (109/l) | 5.1 | 6.4 | 6.3 | |
| CRP (mg/l) | 1.9 | 2.1 | 2 | |
| Cortisol (nM) | NA | NA | NA | |
| Blood pressure (mmHg, systolic/diastolic) | 115/69 | 114/65 | 118/69 | |
| Heart rate (per min) | 57 | 55 | 61 | |
| Temperature (°C) | 36.8 | 36.7 | 36.9 | |
| L4 | Leukocytes (109/l) | 3.6 | 3.7 | NA |
| Neutrophils (109/l) | 2.1 | 2.1 | NA | |
| CRP (mg/l) | 0.3 | 0.3 | 0.3 | |
| Cortisol (nM) | 311 | NA | 202 | |
| Blood pressure (mmHg, systolic/diastolic) | 121/65 | 117/69 | 116/66 | |
| Heart rate (per min) | 67 | 56 | 57 | |
| Temperature (°C) | 35.7 | 36.4 | 36.9 |
Individual monitoring parameters for five volunteers (each recorded by an anonymized case identificiation number) receiving i.d. endotoxin in the standardized endotoxin model. 0, Baseline observations prior to study start; 1, 1 h after endotoxin administration; 6, 6 h after endotoxin administration; NA, data not available at that point.