Table 3.
Toxicity Summary
| Toxicity Type | Treatment Arm (grade) |
|||||
|---|---|---|---|---|---|---|
| A (n = 35) |
B (n = 34) |
|||||
| 3 | 4 | 5 | 3 | 4 | 5 | |
| Hemoglobin | 2 | — | — | 3 | 3 | — |
| Leukocytes | 5 | — | — | 8 | 3 | — |
| Lymphopenia | — | — | — | 1 | — | — |
| Neutrophils | 11 | 1 | — | 9 | 4 | — |
| Platelets | 2 | — | — | 5 | 2 | — |
| Transfusion | ||||||
| Platelets | — | — | — | 1 | — | — |
| PRBCS | 2 | — | — | 6 | — | — |
| Cardiac ischemia | — | — | 1 | — | — | — |
| Edema | 1 | — | — | — | — | — |
| Hypotension | 1 | — | — | 1 | 1 | — |
| Thrombosis/embolism | 1 | — | — | — | — | — |
| Fatigue | 2 | — | — | 8 | 3 | — |
| Weight loss | — | — | — | 2 | — | — |
| Rash/desquamation | — | — | — | 1 | — | — |
| Constitutional | — | — | 1 | — | — | — |
| Anorexia | 1 | — | — | 6 | — | — |
| Ascites | 1 | — | — | — | — | — |
| Colitis | 1 | — | — | — | — | — |
| Dehydration | — | — | — | 2 | — | — |
| Nausea | 3 | — | — | 8 | 2 | — |
| Vomiting | 3 | — | — | 7 | 2 | — |
| Diarrhea without prior colostomy | 1 | — | — | 2 | — | — |
| Melena/GI bleeding | — | — | — | 2 | — | — |
| Infection with grade 3 or 4 neutropenia | 1 | — | — | — | 1 | — |
| Alkaline phosphatase | 1 | — | — | 2 | — | — |
| Bilirubin | 1 | — | — | 1 | — | — |
| GGT | 1 | — | — | — | — | — |
| Hypoalbuminemia | — | — | — | 3 | — | — |
| Asparitate transaminase | 1 | — | — | — | — | — |
| Alanine transaminase | 1 | — | — | 1 | — | — |
| Infection with grade 3 or 4 neutropenia | 1 | — | — | — | 1 | — |
| Infection with unknown ANC | 1 | — | — | — | — | — |
| Infection without neutropenia | 2 | — | — | 1 | — | — |
| Hyperglycemia | 1 | — | — | — | — | — |
| Hypocalcemia | — | — | — | 1 | 1 | — |
| Hypokalemia | 2 | — | — | 2 | 2 | — |
| Muscle weakness | — | — | — | 1 | — | — |
| Abdominal pain | — | — | — | 1 | 1 | — |
| ARDS | — | — | — | — | — | 1 |
| Apnea | — | 1 | — | — | — | — |
| Pulmonary (other) | — | 1 | — | — | — | — |
| Worst degree | 25 | 2 | 1 | 14 | 13 | 1 |
Abbreviations: ARDS, acute respiratory distress syndrome; GGT, gamma-glutamul transpeptidase; PRBCS, packed red blood cells.