Table 3.
Clinical, Pathologic, and Cytogenetic Characteristics of β-Catenin Nucleopositive Medulloblastomas
| β-Catenin Nuclear Immunoreactivity | CTNNB1 Status | XO6 FISH | FISH MYCAmplification/Gain | FISH MYCNAmplification/Gain | XO17 FISH | Pathology | M Stage | Status | Low-Risk Group |
|---|---|---|---|---|---|---|---|---|---|
| W&S | mut (32gac>tac) | Monosomy | No | No | Normal | Classic | M0 | DoD | Yes |
| W&S | mut (32gac>gtc) | Monosomy | Amplified 5%-50% | No | Normal | Classic | M0 | DoD | No |
| W&S | mut (33tct>cct) | Monosomy | No | No | Normal | Classic | M0 | Died* | Yes |
| W&S | mut (34gga>aga) | Monosomy | No | No | Polysomy | Classic | M0 | ADF | Yes |
| W&S | mut (34gga>gaa) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | mut (33tct>tgt) | Monosomy | No | No | Normal | LC/A | M0 | ADF | No |
| W&S | mut (32gac>tac) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | mut (34gga>aga) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | mut (33tct>ttt) | Monosomy | Gain | No | ND | Classic | M0 | ADF | Yes |
| W&S | mut (34gga>gta) | Polysomy | No | No | Polysomy | Classic | M2 | ADF | No |
| W&S | mut (32gac>tac) | Trisomy | No | Gain | Polysomy | Classic | M0 | ADF | Yes |
| W&S | mut (32gac>gtc) | ND | No | No | p loss–ploidy | LC/A | M0 | ADF | No |
| W&S | mut (33tct>tat) | ND | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | mut (32gac>aac) | ND | No | No | ND | Classic | M0 | ADF | Yes |
| W&S | wt | Monosomy | No | No | Monosomy | Classic | M0 | Died† | Yes |
| W&S | wt | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | wt | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | wt | Monosomy | No | No | Normal | Classic | M3 | ADF | No |
| W&S | wt | Normal | No | No | Normal | Classic | M0 | ADF | Yes |
| W&S | ND | Monosomy | No | No | Isodicentric 17q | Classic | M0 | ADF | Yes |
| W&S | ND | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | mut (33tct>ttt) | Monosomy | ND | ND | ND | Classic | M0 | ADF | Yes |
| P&S | mut (37tct>tat) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | mut (34gga>aga) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | mut (32gac>aac) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | mut (33tct>tat) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | mut (34gga>gta) | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | wt | Monosomy | ND | ND | ND | Classic | M3 | ADF | No |
| P&S | wt | Monosomy | No | No | Normal | Classic | M0 | ADF | Yes |
| P&S | wt | Monosomy | No | No | p loss | Classic | M0 | ADF | Yes |
| P&S | wt | Normal | No | No | Normal | Classic | M0 | ADF | Yes |
| P&W | wt | Polysomy | No | No | Polysomy | Classic | M0 | ADF | Yes |
| P&W | wt | Normal | No | No | p loss | Classic | M3 | DoD | No |
Abbreviations: FISH, fluorescent in situ hybridization; M, metastasis; W&S, widespread strong immunoreactivity; mut, mutation; DoD, died of disease; ADF, alive disease-free; LC/A, large cell/anaplastic; ND, not done; p loss–ploidy, p loss on a background of hyperploidy; wt, wild type; P&S, patchy strong immunoreactivity; P&W, patchy weak immunoreactivity.
*
Died as a result of high-grade glioma 11 years after diagnosis.
†
Died as a result of side effects of therapy 2 months after diagnosis.