Table 1.

URB937 levels in the plasma, placenta and fetus of female mice and rats 1 h after drug administration (1 mg·kg⁻¹, s.c. in mice and o.g. in rats) to animals pretreated with either vehicle or Ko-143 (10 mg·kg⁻¹, s.c.; 20 min before URB937)

	Plasma (pmol·mL−1)		Placenta (pmol·g−1)		Fetus (pmol·g−1)
	937	937 + Ko	937	937 + Ko	937	937 + Ko
Mouse	85.6 ± 6.8	80.5 ± 12.2	48.9 ± 6.1	144.8 ± 35.0**	2.4 ± 0.5	6.9 ± 1.2**
Rat	32.4 ± 8.2	30.3 ± 15.7	31.7 ± 1.2	64.5 ± 10.9**	4.4 ± 0.3	8.2 ± 1.1**

Results are expressed as mean ± SEM; n= 3–12.

^**P < 0.01 versus URB937 (1 mg·kg⁻¹).