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. 2012 Nov 29;167(8):1665–1678. doi: 10.1111/j.1476-5381.2012.02120.x

Figure 5.

Figure 5

Effect of TRPV1 and NK1 receptor antagonism on PAR2-induced sensitization of joint fibres. Time course of knee joint afferent activity over 15 min after close intra-arterial injection of 2-furoyl-LIGRLO-NH2 (100 nmol·100 μL−1) alone (n = 21) or 30 min after treatment with SB366791 (500 μg·kg−1 i.p., n = 8) in response to (A) non-noxious and (B) noxious rotation of the joint. Two-way anova followed by Bonferroni test. *P < 0.05 compared with SB366791 pre-treated. Repeated-measures one-way anova followed by Dunnet's multiple comparison test to compare against baseline, ∼P < 0.05. Time course of 2-furoyl-LIGRLO-NH2 (100 nmol·100 μL−1) alone (n = 21), co-administered with RP67580 (2 nmol, n = 11), or RP67580 alone (n = 8) in response to (C) non-noxious and (D) noxious rotation of the knee joint. Data are shown as mean ± SEM. Two-way anova followed by Bonferroni test. *P < 0.05 compared with RP67580 + 2-furoyl-LIGRLO-NH2, #P < 0.05 compared with RP67580 alone, $P < 0.05 RP67580 + 2-furoyl-LIGRLO-NH2 compared with RP67580 alone. Repeated-measures one-way anova followed by Dunnet's multiple comparison test to compare against baseline, ∼P < 0.05.