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. 2012 Nov 29;167(8):1665–1678. doi: 10.1111/j.1476-5381.2012.02120.x

Figure 6.

Figure 6

Effect of PAR2 activation on leukocyte kinetics. Representative intravital microscope images showing the lack of effect of the scrambled peptide (A) and the stimulatory effect of 2-furoyl-LIGRLO-NH2 (B) on leukocyte accumulation in a joint blood vessel. Time course of (C) leukocyte rolling and (D) leukocyte adhesion after perfusion of 2-furoyl-LIGRLO-NH2 (doses 1–1000 μM) or scrambled peptide, 2-furoyl-OLGRIL-NH2 (1000 μM) over 60 min. Data are shown as mean ± SEM, n = 5–6. Two-way anova followed by Bonferroni test. *P < 0.05 1 μM 2-furoyl-LIGRLO-NH2, #P < 0.05 10 μM 2-furoyl-LIGRLO-NH2, $P < 0.05 1000 μM 2-furoyl-LIGRLO-NH2 compared with vehicle. ∞P < 0.05 1000 μM 2-furoyl-LIGRLO-NH2 compared with 1000 μM 2-furoyl-OLGRIL-NH2.