Table 2.
Electrophysiological characteristics and torque used for normal and noxious rotation for each fibre recorded from rat knee joints
| Torque (mNm) | |||||||
|---|---|---|---|---|---|---|---|
| Treatment group | Fibre type | Mechanical threshold (mNm) | Electrical threshold (V) | Conduction velocity (m·s−1) | Normal rotation | Noxious rotation | n |
| 2-furoyl-LIGRLO-NH2 | III | 16 ± 2 | 7 ± 2 | 3.9 ± 1.3 | 16 ± 1 | 33 ± 1 | 6 |
| IV | 19 ± 3 | 7 ± 1 | 1.2 ± 0.2 | 16 ± 1 | 29 ± 2 | 11 | |
| ND | 13 ± 2 | – | – | 16 ± 3 | 22 ± 3 | 4 | |
| SB366791 pre-treated | III | 20 | 5 | 4.8 | 13 | 30 | 1 |
| IV | 11 ± 3 | 7 ± 2 | 1.1 ± 0.2 | 12 ± 2 | 21 ± 5 | 3 | |
| ND | 8 ± 1 | – | – | 11 ± 1 | 23 ± 3 | 4 | |
| RP67580 + 2-furoyl-LIGRLO-NH2 | III | 10 ± 4 | 5 ± 2 | 3.3 ± 0.4 | 15 ± 2 | 27 ± 2 | 3 |
| IV | 14 ± 3 | 7 ± 1 | 1.2 ± 0.2 | 14 ± 1 | 25 ± 4 | 6 | |
| ND | 5 | – | – | 12 ± 4 | 23 ± 8 | 2 | |
Data are mean ± SEM, and fibres are classified as thinly myelinated type III or unmyelinated type IV units. For some fibres, it was not possible to determine conduction velocity. ND, not determined.