Skip to main content
. 2012 Dec;10(4):198–207. doi: 10.1089/lrb.2012.0014

FIG. 2.

FIG. 2.

Compound 48/80-induced inflammatory angiogenesis and lymphangiogenesis in rat mesenteric microvascular networks. (A–D) Representative images over the time course of stimulation. Immunolabeling for PECAM (red) and LYVE-1 (green) identified the hierarchies of branching blood vessel (BV) and lymphatic (L) networks. Increased blood capillary sprouting is observed by 3 days after stimulation (arrowheads), while lymphatic sprouting is increased by 10 days after stimulation (arrows). Scale bar=200 μm. (E–J) Quantification of angiogenesis and lymphangiogenesis in unstimulated mesenteric microvascular networks (Un) and at 3, 10, and 30 days post stimulation. Blood and lymphatic networks were quantified based on PECAM or LYVE-1 immunolabeling, respectively. (E, H) Total vascular area per tissue area. (F, I) Number of blind-ended vessel segments per vascular area. (G, J) Total vascular length per vascular area. * represents a significant difference compared to the unstimulated control group (p<0.05). + represents a significant difference compared to the previous time point (p<0.05). Values are means±SEM.