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Cytotoxicity and anti-HRV-2 activity in non cytotoxic concentrations of virtual hits, selected non virtual hits, and the positive control (pleconaril)
| Compound | CC50 [μg/mL]a | Anti-HRV-2 IC50 ± SD [μM]b |
|---|---|---|
| Pleconaril | 12.6 | 0.03 ± 0.01 |
| 1 | > 50 | 3.19 ± 2.24 |
| 2 | > 50 | 97.08 ± 33.85 |
| 3 | 0.9 | cytotoxic |
| 8 | > 50 | 82.95 ± 43.34 |
| 11 | 32.2 | inactive |
| 13 | > 50 | 11.98 ± 7.53 |
| 14 | > 50 | inactive |
| 15 | > 50 | inactive |
| 16 | > 50 | 91.21 ± 40.27 |
Results from two independent tests.
Results from three independent tests.
