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Effect of anti-ALK antibody on U87 GBM cell invasion of an endothelial cell monolayer. Endothelial cell monolayers were formed on electrodes and the intactness of the monolayer was monitored by electrical impedance sensing. Upon addition of the U87 cells the monolayer is disrupted and this is reflected in real-time as a decrease in electrical resistance of the monolayer. Inclusion of an anti-ALK antibody prevents this disruption (Stylianou et al., 2009).
