Disruption of Rab3A in the mouse results in altered ethanol-dependent behaviors. A, Rab3A−/− and Rab3A+/− mice are resistant to the ataxic effects of 1.5g/kg ethanol in the stationary dowel test. B, Rab3A−/− and Rab3A+/− mice are resistant to the sedative effects of 4g/kg ethanol in the LORR assay. C, Normal ethanol metabolism of 4g/kg IP dose is observed in Rab3A mutant mice; BEC = “blood alcohol content”. Error bars are mean +/− SEM. Asterisks in A and B indicate levels of statistical significance (*, P < 0.01; **, P < 0.001).