Table 1.

Drug and endogenous substrates of MRP4.

Exogenous substances		Endogenous substances
Pharmacological class	Drug	Structural class	Endogenous
Folic acid derivative	Leucovorin	Cyclic and ADP nucleotides	cGMP cAMP ADP
DNA topoisomerase inhibitor	Topotecan* Irinotecan* (SN38)1	Purine analogs	Urate
		Eicosanoids	PGE1 PGE2 PGF2α
Anti-viral	Adefovir†	Folates	Folic acid
	PMEA2,†	Bile acids	Cholate
	Ceftizoxime		Cholytaurine
Tenofovir†
Anti-metabolite	6-Mercaptopurine3,†	Conjugated steroids	DHEAS E217βG
	Methotrexate

PMEA, para-methoxyethylamphetamine; PG, prostaglandin; cGMP, cyclic-guanosine monophosphate; cAMP, cyclic-adenosine monophosphate; ADP, adenosine diphosphate; DHEAS, dehydroepiandrosterone; E₂17βG, estradiol-17-β-D-glucuronide.

Table modified from Russel et al. (2008)

¹Norris et al., 2005

²Schuetz et al., 1999

³Janke et al., 2008

^*Relevant to neuroblastoma treatment; camptothecins

^†Nucleotide and nucleoside analog drugs.