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Sustained hyperglycemia caused changes in expression of genes regulating the cell cycle. The fold changes of gene expression were compared with an OFT from an unopened calibrator for p21 (A) and cyclin D1 (B) for the embryo yolk injected with vehicle, l-glucose, or d-glucose. Data are mean ± SD for n = 10. *Difference from vehicle (P < 0.05) and †difference from l-glucose (P < 0.05) using ANOVA with Fisher LSD post hoc.
