FIG. 4.

Summary of the AUC of IPGTT and IPITT. AUCs of IPGTT test (A) and IPITT test (B) for WT mice (□) and ACE2KO mice (■). Data are presented as the mean ± SEM (mg/dL), n = 4 in each group. *P < 0.05 vs. WT mice that received the same treatment by Student t test. †P < 0.05 vs. genotype-matched, standard diet–fed mice with vehicle infusion by a one-way ANOVA. ‡P < 0.05 vs. HFHS diet–fed WT mice that received losartan alone by Student t test. Ang II, angiotensin II; los, losartan; Ang 1–7, angiotensin 1–7.