Table 2.
The associations between genotypes of genes in PI3K and RAS/RAF pathways and risk of endometrial cancer
| Genotypes | Cases | Controls | Crude OR (95% CI) | Adjusted OR (95% CI)* | P* |
|---|---|---|---|---|---|
| AKT1 rs2498801 | n = 114 | n = 229 | |||
| AA | 48 | 99 | 1.00 | 1.00 | |
| AG | 45 | 106 | 0.88 (0.54–1.43) | 0.90 (0.55–1.48) | 0.669 |
| GG | 21 | 24 | 1.81 (0.92–3.56) | 1.83 (0.92–3.65) | 0.086 |
| AA/AG | 93 | 205 | 1.00 | 1.00 | |
| GG | 21 | 24 | 1.93 (1.02–3.64) | 1.94 (1.02–3.67) | 0.043 |
| PIK3CA rs6443624 | n = 114 | n = 227 | |||
| CC | 73 | 120 | 1.00 | ||
| CA | 34 | 87 | 0.64 (0.39–1.05) | 0.63 (0.39–1.04) | 0.071 |
| AA | 7 | 20 | 0.58 (0.23–1.43) | 0.58 (0.23–1.47) | 0.252 |
| CC | 73 | 120 | 1.00 | 1.00 | |
| CA/AA | 41 | 107 | 0.63 (0.40–1.00) | 0.62 (0.39–1.00) | 0.049 |
| PIK3CA rs9838411 | n = 115 | n = 229 | |||
| GG | 81 | 134 | 1.00 | 1.00 | |
| GA | 29 | 82 | 0.59 (0.35–0.97) | 0.58 (0.35–0.96) | 0.035 |
| AA | 5 | 13 | 0.64 (0.22–1.85) | 0.65 (0.21–1.97) | 0.443 |
| GG | 81 | 134 | 1.00 | 1.00 | |
| GA/AA | 34 | 95 | 0.59 (0.37–0.96) | 0.59 (0.36–0.95) | 0.032 |
| Combined effect (favorable alleles) † | n = 113 | n = 227 | |||
| 0–1 | 46 | 65 | 1.00 | 1.00 | |
| 2 | 35 | 67 | 0.74 (0.43–1.29) | 0.77 (0.43–1.35) | 0.354 |
| >2 | 32 | 95 | 0.48 (0.28–0.82) | 0.48 (0.27–0.83) | 0.009 |
| P trend | 0.008 | 0.009 | |||
* Logistic regression models adjusted for age, ethnicity, and smoking status
† The combined effects were grouped according to numbers of favorable alleles (rs2498801 A, rs6443624 A, and rs9838411 A were considered as favorable alleles)