Table 3.
Association between genotypes of genes in PI3K and RAS/RAF pathways and survival of endometrial cancer
| Genotypes | Patients | Deaths | Crude HR (95% CI) | Adjusted HR* (95% CI) | P* |
|---|---|---|---|---|---|
| PIK3R1 rs1862162 | 113 | 20 | |||
| TT | 65 | 8 | 1.00 | 1.00 | |
| TC | 38 | 11 | 2.67 (1.07–6.65) | 3.59 (1.28–10.10) | 0.015 |
| CC | 10 | 1 | 0.64 (0.08–5.12) | 0.94 (0.11–8.28) | 0.954 |
| TT | 65 | 8 | 1.00 | 1.00 | |
| TC/CC | 48 | 12 | 2.05 (0.84–5.02) | 2.75 (1.03–7.37) | 0.044 |
| AKT2 rs892119 | 112 | 20 | |||
| GG | 77 | 13 | 1.00 | 1.00 | |
| GA | 31 | 5 | 1.05 (0.37–2.99) | 1.23 (0.37–4.06) | 0.735 |
| AA | 4 | 2 | 6.21 (1.37–28.15) | 13.79 (1.13–168.89) | 0.040 |
| GG/GA | 108 | 18 | 1.00 | 1.00 | |
| AA | 4 | 2 | 5.94 (1.35–26.06) | 11.58 (1.07–125.04) | 0.044 |
| PIK3CA rs2699887 | 115 | 20 | |||
| GG | 66 | 12 | 1.00 | 1.00 | |
| AG | 35 | 4 | 0.48 (0.15–1.55) | 0.24 (0.07–0.87) | 0.029 |
| AA | 14 | 4 | 1.48 (0.46–4.73) | 0.73 (0.20–2.66) | 0.633 |
* Cox regression models with adjustment for age, ethnicity, smoking status, histology, stage, and treatment status