Table 5.
Association between genotypes of genes in PI3K and RAS/RAF pathways and recurrence of endometrial cancer
| Genotypes | Recurrence | No recurrence | HR(95% CI) | Adjusted HR* (95% CI) | P* |
|---|---|---|---|---|---|
| KRAS rs7312175 | 28 | 76 | |||
| GG | 13 | 56 | 1.00 | 1.00 | |
| GA | 13 | 18 | 3.33 (1.45–7.63) | 3.59 (1.44–8.92) | 0.006 |
| AA | 2 | 2 | 5.47 (1.17–25.69) | 6.80 (1.27–36.36) | 0.025 |
| GG | 13 | 56 | 1.00 | 1.00 | |
| GA/AA | 15 | 20 | 3.51 (1.57–7.83) | 3.82 (1.58–9.23) | 0.003 |
| PIK3CA rs6443624 | 28 | 75 | |||
| CC | 17 | 47 | 1.00 | 1.00 | |
| CA | 7 | 26 | 0.87 (0.35–2.13) | 1.15 (0.46–2.92) | 0.766 |
| AA | 4 | 2 | 4.07 (1.32–12.59) | 5.86 (1.52–22.63) | 0.010 |
| CC/CA | 24 | 73 | 1.00 | 1.00 | |
| AA | 4 | 2 | 4.2 (1.40–12.58) | 5.22 (1.43–19.03) | 0.012 |
| Combined effect of risk alleles † | |||||
| 0 | 7 | 34 | 1.00 | 1.00 | |
| 1 | 13 | 30 | 2.06 (0.77–5.51) | 2.92 (0.99–9.61) | 0.053 |
| 2–4 | 8 | 11 | 4.57 (1.55–13.48) | 7.36 (1.99–27.15) | 0.003 |
| P trend | 0.006 | 0.003 |
* Cox regression models with adjustment for age, ethnicity, smoking status, histology, stage, and treatment status
† The combined effects were grouped according to numbers of risk alleles (rs7312175 A and rs6443624 A were considered as risk alleles)