. Author manuscript; available in PMC: 2012 Dec 19.

Published in final edited form as: Exp Toxicol Pathol. 2008 May 21;60(4-5):269–280. doi: 10.1016/j.etp.2008.02.010

Table 2.

Benzo(a)pyrene metabolite concentrations and AHH activities in rats inhalationally exposed to 75μg BaP/m³ BaP.

	BaP 7,8-diol⁺ (pmol/gm tissue)	BaP 3,6-dione⁺ (pmol/gm tissue)	AHH activity (nmol 3(OH) BaP/min/mg protein)
		Testis
Control	0.3 ± 0.02	0.5 ± 0.04	0.015 ± 0.004
BaP exposed	17 ± 1.2^*	8.0 ± 0.9^*	0.19 ± 0.04^*
		Lung
Control	0.1 ± 0.02	0.05 ± 0.01	0.023 ± 0.005
BaP exposed	1.0 ± 0.09^*	1.0 ± 0.01^*	0.61 ± 0.05^*
		Liver
Control	0.3 ± 0.02	0.3 ± 0.04	0.017 ± 0.004
BaP exposed	4.0 ± 0.2 ^*	4.0 ± 0.4^*	0.21 ± 0.02^*

p < 0.05

⁺

It is not unusual to have background levels of BaP metabolites in controls as some of these rats may have been inadvertently exposed to carbon black vapor, the vehicle for BaP and which may contain residual levels of BaP. However, the background levels seen in controls were low, and the metabolite data for BaP-treated rats were corrected for control values.