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. 2012 Oct 12;22(2):328–344. doi: 10.1093/hmg/dds431

Figure 7.

Figure 7.

TTT-3002 and LRRK2-IN1 have no effect on neurodegeneration induced by exposure to 6-OHDA or overproduction of DA. (A) GFP worms were treated with different concentrations of TTT-3002 and LRRK2-IN-1 from L1 to L3, exposed to 6-OHDA for 1 h, and re-treated with TTT-3002 and LRRK2-IN1 for another 24 h. The DA neurons were monitored from 0 h (L3), 24, 48 and 72 h after 6-OHDA exposure. No significant improvement of DA neuron survival in TTT-3002 and LRRK2-IN1 treatment groups were observed. (B) The CAT-2 overexpressing C. elegans were treated with different concentrations of TTT-3002 and LRRK2-IN-1 from L1–L4. CAT-2 overexpression generates excessive dopamine and leads to DA neuron degeneration in C. elegans on adult Day 4. The DA neurons were monitored at L4 stage and on adult Day 4. No change in DA neuron survival was observed between vehicle controls and groups treated with TTT-3002 or LRRK2-IN1.