Figure 4.

Pancreatic fractional β-cell area (A) and computed β-cell mass (B) in lean nondiabetic subjects from 20 to 100 years of age. Pancreatic fractional β-cell area increased with age (A), but when β-cell mass was calculated from pancreatic parenchyma (Supplementary Fig. 1), β-cell mass remained constant to advanced age (B). The mean individual β-cell cross-sectional area (C) and β-cell nuclear diameter (D) both increased with age.