Figure 3.

Proliferative capacity of antigen-specific T cells in human immunodeficiency virus (HIV) infection. Collated flow cytometric data demonstrating the proportion of CD3⁺CD8^– T cells proliferating in response to wild-type (WT) cell culture supernatants (A), Mycobacterium tuberculosis (MTB) purified protein derivative (B), and influenza (C) in HIV-uninfected (circles: WT n = 26, MTB n = 23, Flu n = 26), HIV-asymptomatic (squares: n = 26), HIV-symptomatic (triangles: WT n = 24, MTB n = 15, Flu n = 23), and HIV-infected individuals established on antiretroviral therapy (ART) for 6–12 months (inverted triangles: WT n = 24, MTB n = 17, Flu n = 16) or ≥18 months (diamonds: WT n = 18, MTB n = 8, Flu n = 20). Gray data points represent individuals who were positive for pneumococcal nasopharyngeal carriage. Black horizontal bars represent median values of total antigen-specific responses above background. Statistical significance was analyzed by the Mann-Whitney U test. Differences were considered significant if P ≤ .05.