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. 2012 Oct 5;40(22):11583–11593. doi: 10.1093/nar/gks910

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Methylation of adenosine and guanosine at position 9 of human (mt)tRNAs. (A) Enzymatic methylation of the N¹ of adenosine using SAM as the methyl group donor and release of S-adenosyl homocysteine (SAH). (B) Cloverleaf structure and modified nucleotides of human (mt)tRNA^Lys. (C) Enzymatic methylation of the N¹ of guanosine. (D) Cloverleaf structure and modified nucleotides of human (mt)tRNA^Ile.