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. 2012 Oct 12;40(22):11697–11713. doi: 10.1093/nar/gks927

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 8. — Impact of the non-structural proteins coding sequence on IRES folding. Summary of significant reactivity differences (P ≤ 0.05) observed in DMS and SHAPE profiles for the replication-competent RNA molecule (Rep) with respect to transcript I. Filled circles: significant increase (P ≤ 0.05) in NMIA reactivity in Rep with respect to molecule I; open circles: significant reduction (P ≤ 0.05) in NMIA reactivity for Rep with respect to construct I; filled triangles: significant increase (P ≤ 0.05) in DMS reactivity in Rep with respect to construct I; open triangles: significant reduction (P ≤ 0.05) in DMS reactivity in Rep with respect to construct I; grey squares: noisy residues.